The signalling pathway of BimL and BimS, two isoforms of the BH3-only protein Bim, in apoptosis
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چکیده
discussions, for sharing her expertise and for her constant encouragement. Also, I am tremendously thankful to her for introducing me to the Berlin culture, for dragging me to kick boxing classes and for always reminding me that the chestnut trees blossom beautifully! I am mostly indebted to Ana Milojkovic for her true and unconditional friendship, for her trust, for her care and for sticking by me no matter what. I am genuinely grateful to her for spending hours on the phone without me talking, for teaching me about colour matching bags and shoes and for telling me her stories from Kreuzberg. Мoжeш ce да направиш !! Cе ке биде супер !! Last but not least, I am deeply grateful to my whole family and Christian Mauch for their love, support, understanding and patience. Without their help I could not have accomplished this work. Index Erklärung 2 Acknowledgements 3
منابع مشابه
B cell receptor-mediated apoptosis of human lymphocytes is associated with a new regulatory pathway of Bim isoform expression.
Studies in Bim-deficient mice have shown that the proapoptotic molecule Bim plays a key role in the control of B cell homeostasis and activation. However, the role of Bim in human B lymphocyte apoptosis is unknown. We show in this study that, depending on the degree of cross-linking, B cell receptors can mediate both Bim-dependent and apparent Bim-independent apoptotic pathways. Cross-linked an...
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Other names: BAM, BIM, BIM-alpha6, BIM-beta6, BIM-beta7, BOD, BimEL, BimL HGNC (Hugo): BCL2L11 Location: 2q13 Local order: According to GeneLoc and NCBI Map Viewer, genes flanking BCL2L11 in plus strand direction are: ACOXL 2q13 (acyl-Coenzyme A oxidase-like); PAFAH1P2 2q13 (platelet-activating factor acetylhydrolase, isoform Ib, pseudogene 2). Note: BCL2L11/BIM is a BH3-only protein from the B...
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متن کاملA Convoluted Way to Die
velopment is initiated by transcriptional upregulation of Ivelisse Sánchez and Junying Yuan* Egl-1, another BH3-only member of the BCL-2 family Department of Cell Biology that acts by inhibiting Ced-9, an antiapoptotic member Harvard Medical School of the BCL-2 family (Conradt and Horvitz, 1998). 240 Longwood Avenue BIM may not be the only BH3-only member that is Boston, Massachusetts 02115 ind...
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تاریخ انتشار 2010